Insulin Resistance as a protective mechanism at the cellular level.
Great podcast with some intriguing thoughts on insulin resistance. The discussion is at about 3.5 to 8 minutes. Tommy sees it as a protective mechanism at the cellular level against excess energy, inflammation, and oxidative stress. It was illuminating to me as the body in my orientation/viewpoint, in most cases, is invoking mechanism to deal as best as possible with what is being thrown its way.
It also provides mechanisms for why low-carb real food and more movement was so effective at healing a wide-range of issues I had: I reduced energy intake (voluntarily), reduced inflammation, and oxidative stress (becoming a ‘fat-burner’ is generally associated with less oxidative stress). I gave my cells a healthier internal environment that did not invoke oxidative stress. Had no idea I was doing this at the time but might be why it was ‘crazy effective’.
Hyperinsulinemia and hyperglycemia are also at play here of course. In terms of diet choices I now think not just carbs, but novel industrial carbs, how much we eat of them, how constantly, set up novel non-evolutionary responses in our insulin system hormones.
All these insulin and glucose ‘hyper-spikes’ are non-evolutionary insults past system tolerance and wear our systems out quicker. All the sugars and flours and processed carbs can trigger so high a glucose and insulin response so frequently that chronic (lifestyle) insulin resistance can happen much quicker.
And I just read a Mark’s Daily article today on the inflammatory effects of seed oils at the mitochondria/cellular level. I will link it in comments. Ties back perfectly to Tommy’s three mechanisms. Plus refined carbs and starches for me at least provoked the excess eating/excess energy environment. I also had chronic inflammation.
Enjoyed the whole podcast but those five minutes are worth it for those interested in insulin resistance, chronic diseases. Fascinating stuff on effective lab tests and intermediates also.